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Free eBook The biochemical basis of neuropharmacology download

by Jack R Cooper

Free eBook The biochemical basis of neuropharmacology download ISBN: 0195940369
Author: Jack R Cooper
Publisher: Oxford University Press; 5th edition (1986)
Language: English
Pages: 400
Category: Medicine
Subcategory: Pharmacology
Size MP3: 1415 mb
Size FLAC: 1553 mb
Rating: 4.6
Format: lrf mbr rtf lrf

Jack R. Cooper, Professor of Pharmacology, School of Medicine, Yale University.

Jack R. Robert H. Roth, Professor of Pharmacology and Psychiatry, School of Medicine, Yale University.

Cooper, Jack . 1924-; Bloom, Floyd . joint author; Roth, Robert . 1939- joint author. Books for People with Print Disabilities. Internet Archive Books.

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The Biochemical Basis of Neuropharmacology. Cooper is at Yale University, School of Medicine (Emeritus). Bibliographic information. The Biochemical Basis of Neuropharmacology. Jack R. Cooper, Floyd E. Bloom, Robert H. Roth. Oxford University Press, 2003.

Discussions of drugs are included as they relate to the particular neurotransmitter under examination. Categories: Chemistry.

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Dopamine synthesis also depends on the rate of impulse flow in the dopaminergic pathway (Cooper et al. 1996). Dopamine is released in a calcium-dependent manner when an action potential invades the terminal of the neuron. Effect of Nicotine on Dopaminergic Neurotransmission and Expression of Fos Protein. On the basis of their functional, anatomical, and physiological properties, it is argued that cortical columns may be treated as the basic dynamical modules of cortical systems. Coupling between these columns is introduced to represent sparse long-range cortical connectivity.

User reviews
This edition works for someone who wants to learn the basics of Neuropharmacology, which I bought it for. However, there are several more complex drugs which appeared in the market in the past two decades and I would like to know what are the biochemical interaction subtleties and differences of these new drugs compared the basic processes.

Overall, I learned a lot and the book assisted me in my understanding of the subject I am currently studying.
This is a classic. There is no attempt to be encyclopedic but, rather, to cover some (advanced) basics and to illustrate the thinking and approaches employed in this field. I am sorry not to see an update.
This text intermittently colloquial and technical looking for something that includes biochemistry yet found it interesting.
This book be bawlin, and you'll need a dictionary to be able to understand half the words in it, but daaaaawn.
I really don't remember getting this so I can not say anything about it. I am sure it is an okay book.
Completly disappointing. !
This reference is easy to read. As well, unlike most pharmacology texts, this one does not concentrate on drugs, but rather on the underlying physiology. There is an introduction to neurons, synapses and action potentials. There is an introduction to modern molecular methods. It is interesting to note that in describing molecular cloning methods, the work of J. G. Sutcliffe, R.J. Milner, and F.E. Bloom is reported whereby a cDNA library was prepared from mRNAs from whole rat brain, then it was seen what individual cDNAs hybridized with the mRNAs from rat liver and kidney. Approximately 30,000 of the brain's 50,000 mRNAs were not detected in the liver or kidney, showing that much of the rat's DNA is for neuronal purposes. In the introduction to receptors, it is noted that there about a thousand known receptors to neurotransmitters, hormones and odorants. The introduction to neuromodulators includes the neuronal effects of nitric oxide (thought to be involved in both long-term potentiation LTP and long-term depression LTD; nitric oxide synthase inhibitors will block NMDA receptor activation). The chapter on amino acid neurotransmitters includes excitatory glutamate and aspartate, and inhibitory GABA, glycine, alanine, cystathionine and serine. There are chapters on cholinergic (acetylcholine) and catecholaminergic (norepinephrine, epinephrine and dopamine) neurotransmitters. Serotonin and histamine neurotransmitters are considered in detail in the next chapter. There is an introduction to neuroactive peptides, noting that they must be synthesized on ribosomes, then at the smooth endoplasmic reticulum they are put into vesicles in a prohormonal form, and only then transported to the nerve terminals. The book concludes with introductions to the cellular mechanisms involved in learning, and the involvement of neurotransmitters in neurological and psychiatric illnesses.
Although a bit dry in parts, it gives a good picture overall of how neurotransmitters and brain receptors work. A comprehensive book about the fields of neurochemistry and neuropharmacology.